Revolutionising gluten-safe food production

Background

Prozymi Biolabs Ltd, an Edinburgh based biotechnology start-up was founded with a mission to revolutionise gluten-free food production. With a significant portion of the UK population affected by gluten-related disorders, including coeliac disease, gluten sensitivity and IBS, there is an increased demand for gluten-free products. However, existing gluten-free options often lack the taste, texture, and nutritional value of traditional gluten-containing foods, posing challenges for consumers.

Scientists from Prozymi Biolabs are testing a new enzyme technology that degrades gliadin, the protein that causes food sensitivities.

The Journey

Since its inception in early 2021 Prozymi Biolabs has experienced rapid growth and made a significant impact in the biotech world – more specifically in gluten-safe technology.

Co-founders Ioannis Stasinopoulos and Andreas Andreou were awarded their PhD’s at the University of Edinburgh and came up with the idea of developing a pioneering method of making gluten-safe bread while baking sourdough bread in their spare time. Receiving seed funding through the University of Edinburgh’s Data Driven Entrepreneurship program, which supports high growth start-ups associated with the university, gave Prozymi Biolabs the kick-start required to embark on their journey revolutionising the gluten-free bread experience.

Following an introduction via the student enterprise team at Edinburgh Innovations, Louise Arnold, Business Engagement Executive at Interface, has supported the Prozymi Biolabs team since they started, helping them navigate the academic research and development landscape, making relevant connections into universities, support networks and funding.

Some of these connections and projects include:

• Queen Margaret University and the SRUC Thrive Programme in support of product development, planning, marketing, pitching, nutrition, food legislation and access to general business support information.
• The Industrial Biotechnology Innovation Centre (IBioIC) Accelerator Programme, to guide and assist them on best practice, direct innovation support and peer to peer learning. They continued to collaborate with IBioIC, through the scale up of the gliadin-degrading enzymes using IBioIC’s scale up facilities at Heriot Watt University.
• Two projects with University of Aberdeen’s Applied Health Science students: one to identify the causes behind gluten disorders, the parts of gluten responsible, the key symptoms, diagnostic methods, and potential treatments used. And the second on gluten awareness, researching gluten-related topics such as gluten intolerance, celiac disease, and gluten-free diets analysing data collected to identify patterns, trends, and key insights regarding gluten-related issues.
• A collaboration with University of Stirling’s Business School students on developing marketing strategy and market and competitor analysis.
• A partnership with the Proteomics and Metabolomics Facility at the University of Edinburgh’s Roslin Institute, funded via the Healthier Products Innovation Fund, allowed Prozymi Biolabs to use their mass spectrometry equipment to develop a robust process for sequencing and characterizing gluten-degrading enzymes. This collaboration enabled the identification and expression of candidate enzymes, with a focus on specificity and efficiency in degrading harmful gluten peptides while preserving the integrity of bread’s texture and flavour.

The Benefits

Prozymi Biolabs are creating employment opportunities, generating collaborations with university facilities and provide experiential learning opportunities for students through Interface support. The project outcomes could yield multidimensional benefits in the future as follows:

• Social: Consumers will benefit from high-quality gluten-free products at lower prices, making them affordable for low-income social classes.
• Economic: The low production cost of gluten-free products made with their technology will alleviate NHS financial burden for prescribed goods to coeliacs and help products of those higher in the supply chain, such as local wheat and barley suppliers to reach the gluten-free market.
• Environmental: Reduced reliance on imported naturally gluten-free materials, used for existing gluten-free products, will minimise transport fuels and align with government priorities for carbon footprint reduction.
• Political: Support the government’s strategy for locally sourced wheat and barley grains to increase nation’s self-sufficiency and resilience.

Benefits to Prozymi Biolabs

• Collaboration has fostered an innovative environment, leading to the development of a Minimum Viable Product (MVP) through identification and characterisation of the gluten degrading enzymes. This has also enhanced overall productivity within the company.
• By pooling resources and expertise across the university networks, has led to increased R&D efficiency, cost savings and faster project completion. The collaborations have improved Prozymi Biolab’s market position enabling the development of cutting-edge solutions, while increasing their market valuation.
• Potential applications in brewing, animal feed, and pharmaceutical industries.
• This innovation has also led to the selection of Prozymi Biolabs for IBioIC’s Biotech Innovators incubator, University of Edinburgh’s Venture Builder Incubator, Barclay’s AgriTech Bridge program and Carbon 13 Venture Launchpad program opening avenues for further academic and research collaborations.
• Awarded Innovation of the Year at the Scottish Knowledge Exchange Awards 2024.

Benefits to Academics

• The partnership has provided the University of Edinburgh’s Proteomics & Metabolomics Facility with an opportunity to apply analytical chemistry tools in the food sector.
• Collaborating with the organisation has opened additional funding opportunities for the universities, allowing for expanded research capabilities.
• The collaboration has offered students the chance to engage directly with industry, enriching their learning experience and professional development.

Next Steps

Prozymi Biolabs’ innovative approach to gluten-free bread production has the potential of transforming the food industry, offering consumers high-quality gluten-free products with improved taste, texture, and nutritional value. Through collaboration with academic partners and participation in incubator programs, the company is poised to further advance its research and development efforts, paving the way for a new era of gluten-free innovation.

Next steps for Prozymi Biolabs include:

• Continued collaboration with the University of Edinburgh’s Proteomics and Metabolomics facility and Edinburgh Genome Foundry has resulted in an established pipeline for screening and expression of gluten-degrading enzymes which could be further developed to generate new promising candidates in the future for the needs of beer, pharma, or animal feed industries.
• New academic collaborations with Queen Margaret University Scottish Centre for Food Development and Innovation, to provide equipment and expertise for small-scale proof-of-concept gluten-free bread production; the School of Physics of the University of Edinburgh for potential collaboration for testing the rheological properties of initial gluten-free bread batches.

Innovation, new ideas and emerging technologies in the world of food are constantly being explored and developed across a wide array of fields, disciplines, topics and specialities. However, engagement between the wide range of different subjects in which food features is often limited.

This conference will open up inter-disciplinary boundaries and blind-spots, focussing in particular on what innovation looks like and means across different areas of study involving food.

In inviting all those interested in and engaged with food to discuss what’s considered new, progressive and important from different perspectives, the conference seeks to inspire fresh thinking and improve our understanding of how food works not just in different sectors, but in the world as a whole.

“Being Innovative about Food Innovation” is a two-day event that aims to bring together a diverse community of individuals engaged with researching, studying and working with food. It’s not a standard academic conference, in that it seeks to both champion and challenge different ideas about innovation, inviting contributions in a variety of formats as a means to broadening and improving our thinking on one topic. Whether you are an academic, a researcher, nutritionist, dietitian, chef, cook, food provider, food organiser, food scientist, food educator, agronomist, grower, food producer, brewer, fermenter, marketer, communicator, government official or student, this conference offers a unique opportunity to connect, share knowledge and gain insights not just into the latest trends and breakthroughs in the food sector, but to consider different concepts of what innovation and progress mean.

Howell Davies, Interface’s Head of Strategic Programmes & Funding will be presenting on “How do you define Innovation for the Food & Drink Sector?”

Knowledge Transfer Partnerships create dynamic connections between businesses and the UK’s world class knowledge bases to deliver strategic innovation projects.

The KTP Roadshow is aimed at businesses, charities, academics and researchers interested in learning more about how Knowledge Transfer Partnerships can create relationships to transfer knowledge by bringing together companies seeking knowledge and academics and researchers with knowledge.

The Building Knowledge Transfer Partnerships roadshow is an opportunity for companies to come to Queen Margaret University to meet academic and research staff and learn more about Knowledge Transfer Partnerships.

The roadshow will spotlight and share insights on collaborative research and development opportunities with QMU, as well as share useful guidance on the support available from the East of Scotland KTP Centre for developing bids for government funding.

Interface is presenting at this event.

Background

Headquartered in Glenbervie near Stonehaven, Scotland, Macphie is the UK’s leading, independent, added-value food ingredients manufacturer, and has been producing premium quality food ingredients and solutions for customers across 40 countries for over 85 years.

Challenge

The company approached Interface to seek help in finding relevant academic collaborators to provide solutions to a range of challenges facing their business. These ranged from reducing saturated fat content and creating “cleaner label” products to rethinking their packaging and storage.
 

Solution

Interface has facilitated a series of collaborative projects with numerous Scottish Universities to support the business challenges.

Project areas have included:

• Use of Ultrasound in thermal processing to control food structure
• Mechanical Engineering projects on packaging and energy efficiency
• Starch/ protein chemistry for surface modification
• Stabilisation of food emulsions
• Packaging and Manufacturing Process Optimisation
• Chemical Engineering – UHT process flow characterisation and improvement
• New packaging designs for sustainability and manufacturing efficiency improvement
• Sugar reduction in key products

To date, Macphie has been involved in more than 15 individual collaborative research projects with multiple universities which have yielded cost savings to the business of many hundreds of thousands of pounds.
 

Business benefits

“Innovation is a cornerstone for Macphie, developing new technologies, products, processes and packaging to add value to our business and better meet our customer needs.

Macphie utilises Interface as a Scottish brokering service that brings businesses and universities together. Interface has facilitated a series of collaborative projects across a range of business requirements with Scottish universities. Using the Interface network, we have managed to completely accelerate our innovation agenda.

At Macphie we now have a rich heritage of academic projects across many aspects of our business. These translate into shaping and driving our innovation agenda. Interface is a crucial partner in enabling us to pair up with the very best academic organisations to achieve success. Our ongoing outlook is to continue to invest resources in long-term, transformational projects to ultimately add even greater value to our customer offering.” Martin Ruck, Macphie’s Head of Research and Development.

Academic benefits

Following a successful masters project with Abertay University on computer and web Enabled Food Product Evaluation System:

“Abertay has a specific interest in pursuing links with industry as part of the University’s Strategic Plan. The work with Macphie is an excellent example of how Abertay can be recognised for developing graduates equipped with the attributes and attitudes to contribute significantly to future economies. 

The work has also been conducive for developing pathways to impact, allowing Abertay to generate an excellent track record with respect to KE activities that generate further income and reputation for the University.”  Dr Nia White, Head of the Graduate School, Abertay University.

Interface also supported Macphie and the University of Edinburgh to develop and test a series of emulsions to use in a commercial setting. This led on to further studies on the role of fat crystallisation in the process of stabilizing emulsions and foams which enabled the company to increase the unsaturated fats in their products.

“It was very interesting for us to apply our expertise in the physics of emulsion technology to support a company developing healthier products.”
Dr Tiffany Wood, Director of the Edinburgh Complex Fluids Partnership, The University of Edinburgh.

Additional notes

Macphie have worked with the following Universities and Research Institutes: University of Edinburgh, Glasgow Caledonian University, University of Strathclyde, Heriot-Watt University, Rowett Institute of Nutrition and Health at the University of Aberdeen, Robert Gordon University, Abertay University, Queen Margaret University.